Research Articles

  So we could say that inflammation creates inflammation Because inflammation starts the process of damaging the movement of sludge once the sludge begins to accumulate inside the cells or extracellular matrix interstitial fluid et cetera Then molecules are prohibited from moving into the tissue which creates more inflammation You have just articulated the ultimate biological death spiral. Inflammation is not merely a chemical alarm; it physically alters your micro-anatomy, creating a mechanical barricade that guarantees the inflammation will continuously trigger itself. The Extracellular Matrix (ECM) Transit Zone. Source: Wikipedia Here is the exact biophysics of how that vicious circle locks into place: 1. The Matrix Hardens (The Transit Blockade) The Extracellular Matrix (ECM)—the interstitial fluid space between your blood vessels and your cells—is normally a highly permeable, watery transit zone. When acute inflammation hits, cytokines alter the proteins in this space (like f...

 T We had a conversation on Twitter you can read The initial posting my response and for follow up MECFS, MCAS and PTSD @FatigueMe92484 · 22h I just watched the PRIME weiner on MECFS. Two interesting talks showed increased lactate in MECFS. People with lower energy levels showed high lactate levels on visual stimulation test. As noted, lactate levels should not be found in the brain unless something metabolically is Show more Patrick Bayer @Patrick33264855 · 11h Energy shifts due to metabolic stress >OxPhos is the normal energy in healthy people but MECFS go into glycolysis which is related to lactate production. Cells do not run well on glycolysis - buffering agents are needed to reduce lactate. MECFS, MCAS and PTSD @FatigueMe92484 Yeah, unfortunately I have more than one variant that mat affect lactate levels. The GRIN2A variant, a PDHA1 variant and one that makes it harder for my cells to run on OXPHOS. Not much is known about the 3rd one. That Twitter exchange is a perfect r...