Research Articles

Excerpt from article: In combination therapy, synergy is said to occur when the combined effect is greater than the sum of the individual effects. An additive effect is observed with the combined effect which is equal to the sum of the individual effects. Indifference is observed when there is no interaction between one another. Antagonism is defined when the combined effect is less than when the two compounds are individually applied. The reversal of resistance is said to occur when a synergistic outcome is observed. As an example, one of the strategies employed was to screen against β-lactamase producers and by mechanism-based inhibition of the active-site serine hydrolases for compounds that can antagonize the antibiotic-destroying hydrolases. Clavulanic acid (sulbactam or tazobactam) from a streptomycete in combination with amoxicillin was the outcome of this approach [34]. However, the victory against bacterial resistance did not last long; the frequent use of clavulanic acid ...

A continuation of the previous article concerning antibiotic resistance and essential oils. Here are some of the pathways resistant organisms use: THE PREVALENCE OF RESISTANCE MODIFYING CAPABILITY BY ESSENTIAL OILS Antimicrobial agents are classified based on their principal mechanisms of action. These mechanisms include interference with cell wall biosynthesis (β-lactams and glycopeptides agents), inhibition of bacterial protein synthesis (marcolides and tetracyclines), interference with nucleic acid synthesis (fluroquinolones and rifampin), inhibition of a metabolic pathway (trimethoprim-sulfamethoxazole, and disruption of bacterial membrane structure (polymyxins and daptomycin) [9]. Three main targets of antibiotics are cell wall, protein and nucleic acids biosynthesis. Throughout the years since antibiotic was introduced, bacteria have acquired various resistances to survive in the deluge of antibiotics. The mechanisms vary and make the work of mitigating the spread of resistance ...

It ain't always easy. Johannes Haushofer has posted his C.V. of failures which is an interesting look at the struggles we all face in life. For some, the doors open easy while for others, they are bolted, welded and sealed shut. Persistence is key and understanding that we are just human helps us in the journey. www.princeton.edu/~joha/Johannes_Haushofer_CV_of_Failures.pdf princeton.edu

http://nautil.us/issue/56/perspective/antonio-damasio-tells-us-why-pain-is-necessary F ollowing Oliver Sacks, Antonio Damasio may be the neuroscientist whose popular books have done the most to inform readers about the biological machinery in our heads, how it generates thoughts and emotions, creates a self to cling to, and a sense of transcendence to escape by. But since he published  Descartes’ Error  in 1994, Damasio has been concerned that a central thesis in his books, that brains don’t define us, has been muted by research that states how much they do. To Damasio’s dismay, the view of the human brain as a computer, the command center of the body, has become lodged in popular culture.

Twenty-seven years ago, a group of physicists made an accidental discovery that flipped mathematics on its head. The physicists were trying to work out the details of string theory when they observed a strange correspondence: Numbers emerging from one kind of geometric world matched exactly with very different kinds of numbers from a very different kind of geometric world. Mathematicians Explore Mirror Link Between Two Geometric Worlds | Quanta Magazine

Twenty-seven years ago, a group of physicists made an accidental discovery that flipped mathematics on its head. The physicists were trying to work out the details of string theory when they observed a strange correspondence: Numbers emerging from one kind of geometric world matched exactly with very different kinds of numbers from a very different kind of geometric world. Mathematicians Explore Mirror Link Between Two Geometric Worlds | Quanta Magazine

Scientists suggest that cancer is man-made Cancer is a modern, man-made disease caused by environmental factors such as pollution and diet, a study review by University of Manchester scientists has strongly suggested. https://www.manchester.ac.uk/discover/news/scientists-suggest-that-cancer-is-man-made/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906676/

https://www.quantamagazine.org/a-proof-about-where-symmetries-cant-exist-20181023/

https://www.quantamagazine.org/a-unified-theory-of-randomness-20160802

Amplituhedron theoryofeverything.org/MyToE/wp-content/uploads/2013/11/amplituhedron-0c.png

https://www.quantamagazine.org/physicists-discover-geometry-underlying-particle-physics-20130917

Dr. Horowitz is a doctor who get this. He has coined a new phrase which is called MFIDS - Multiple Systemic Infectious Diseases Syndrome which embraces a number of diseases such as Lyme, M.E. (CFS), MS and others. These diseases start in the immune system and migrate out into endocrine, neurological, metabolic diseases etc. http://www.publichealthalert.org/-interview-with-dr-horowitz.html Interview: Dr. Richard Horowitz, MD, Author of "Why Can't I Get Better: Solving The Mystery of Lyme & Chronic Disease"

Nfr2 Pathways. A look a pathways that are very important. http://www.drperlmutter.com/changing-gene-expression-powerful-anti-aging-medicine/?hvid=4Naflt#more-2982

On being human. I like this post and think it offers some good insight. It focuses on how to be human from a perspective of self rather than societal's viewpoints. Yes you have reasons why you are doing the things you are doing, think your thoughts and act the way you do. We as humans are a brewing pot of many experiences from the time we were born until today. We form consciousness which provides a rail for our daily encounters. There is a reason. Do You Really Know Yourself?

An interesting article on a new concept called Adaptive Homeostasis. Homeostasis is self regulating actions within the body that allow adaptation. For instance if you are cold then the body triggers certain functions to balance this. There are a number of self regulating actions within the body that encompass endocrine, immune, neurological etc. This article talks about adaptive homeostasis where instead of a recent action and a recent change, adaptive includes longer term incidents say toxin exposure. The author states that the body is equipped to make major and permanent changes through events such as gene expression. What prompted me was a person I know who contracted M.E. who is disabled. With the onset, she became sick but the disease stopped there, in other words did not progress. She is still disabled but functional. Synopsis: The body is an amazing creation. Adaptive homeostasis sciencedirect.com

https://www.youtube.com/watch?v=xLgaoorsi9U

For a long time the medical community believed that autoimmune diseases was caused by the immune system attacking itself. New research shows that this theory is wrong and the real issue is the role of infectious organisms being the culprit. High immune activation causes many side effects due to the high ROS & RNS created by immunity. The role of infections in autoimmune disease

Host Immune Response to Intestinal Amebiasis journals.plos.org no comments no plus ones

Intensions on Market Psychology Intensions on Market Psychology

Top 7 Acupressure Points for Complete Detoxification By  Bipasha Mukherjee   7 Comments Recurrent illness and chronic diseases like joint pain and arthritis are often the cause of toxic overload in the body. Excessive dependence on junk and processed foods, pollution and food additives increases the level of toxins in the body and hinders the proper functions of the organs leading to pains, aches, fever and tiredness by lowering the body’s defense mechanism. Detoxification can be done by drinking plenty of water, fating, making dietary changes. But one of the best and long lasting ways of detoxification is thought  acupressure points  and reflexology. The benefits of reflexology are innumerable and it helps in flushing out toxins form the body by stimulating qi flow through the important organs involved in detoxification – liver, kidney, colon, lungs and skin. https://www.modernreflexology.com/acupressure-points-for-body-detoxification/

An interesting article on the role of chronic stress on the endocrine system. The HPA axis is a 3 gland relay system that regulates much of the system including neurological. It is triggered under stressful conditions and as a result then changes in the body occur.  Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the ro... - PubMed - NCBI ncbi.nlm.nih.gov

Sharing an interesting article concerning the role of neurotransmitters and addictions. I am thankful that this has not been an issue for me but I saw loved ones suffer. Unfortunately the medical establishment solution is behavior modification which statistics show as being an absolute failure. The mind is a cellular organ meaning it requires baseline nutrients to produce valuable neurotransmitters.  Addictions of any sort be it shopping, alcohol, prescription drugs, shopping, porn, social prestige etc are all signs that the neurons are not functioning at full capacity. These activities  release dopamine and opiate-like substances such as endorphins and enkephalins. Substance P (P = Pain) is another neurotransmitter that is found in the brain and they find high levels of it in addicts. So in order to quench Substance P they resort to activities that raise neurotransmitters that kill the pain (dopamine, endorphins etc).  There is no question that counseling can help u...

An interesting article on Th1/Th2 immune reactions. The immune system is a powerful system that influences many parts of the body including metabolism, neurological, endocrine and other systems. The body can lean towards a Th1 or Th2 dominance, the author outlines the many facets.  Are You Th1 or Th2 Dominant?

Neuroinflammation causing problems.  Her Brain Was On Fire: A Neuroinflammation Story - Health Rising cortjohnson.org one comment 1 no plus ones no shares Shared publicly Patrick Bayer Infections will alter the rest of the body. Neurological function is altered with strong immunity.  The author describes the harrowing battle to find reasons for destroyed health.