Research Articles

 , there is a very significant and important relationship between Paneth cells and short-chain fatty acids (SCFAs) . It's a key interaction in maintaining gut health and is a great example of the complex interplay within the gut ecosystem. Here's how they relate: SCFAs Stimulate Paneth Cell Function: Butyrate (a key SCFA): Research has shown that butyrate, one of the most abundant and beneficial SCFAs produced by gut bacteria (especially from resistant starch fermentation), can directly stimulate Paneth cells to secrete their antimicrobial peptides (AMPs), particularly alpha-defensins (cryptdins) . This is a crucial feedback loop: beneficial bacteria produce SCFAs, and these SCFAs then tell the Paneth cells to ramp up their production of "antibiotics" that help control the overall microbial balance. This stimulation helps Paneth cells perform their role as "curators" of the gut microbiome, ensuring that the beneficial bacteria can thrive while potentially...

 Educational only: Keep in mind that the system is really a networked system meaning that one system, say neurology can impact other systems such as endocrine, immunity etc. The gut contains 70% of the immune system and when immunity is triggered, it can seep into other systems, particularly the neurological. The gut/brain axis is well established and now they know that many neuropsychiatric conditions have origins the gut. Examples of this are Parkinson's disease or Autism, but also more common problems like depression, anxiety etc. There are several explanations that I will not go into but primarily, it is the immune responses that are occurring within the gut mostly due to a gut whose microbiome is out of balance.  Sleeping issues can be a telltale sign of some immune triggering, insomnia is one of those which in my case is due to histamine release, that is why anti-histamines tend to help me fall asleep. Histamine is a byproduct of immune activation.  The gut/brain ax...

 Disclaimer: Making sure that you know I am not a doctor which means I cannot provide a diagnosis or treatments. My opinions are my own and do not represent Donato's. The studies are pretty solid concerning the role of the gut to the brain, aka as the gut/brain axis. They know that many neuropsychiatric conditions are related to the gut, particularly what bacteria are growing too strongly (e.g. bad bacteria) and generally, not enough good bacteria are growing. In terms of neuropsychiatry, this would refer to Alzheimer's, dementia, depression, anxiety and autism.  The gut was once thought to be just a disposal vessel but now it is understood to be a very dynamic system that involves quite a few functions that mitigate to the rest of the body including the brain.  A large part of the immune response resides in the gut - they estimate this to be 70% of the immune system. Of course, with immunity, inflammation comes. Inflammation is really a byproduct of immune activation....