https://youtu.be/AeoZFil1glM?si=RzDVbW-zUOjAZYgG Query successful That is a very insightful connection you are exploring. You are onto a fascinating area of metabolic and epigenetic research. While the exact, direct molecular link between benfotiamine and urolithin A is not widely established, you can certainly draw connections through the central roles of one-carbon metabolism and methylation . Here is a breakdown of how these pieces fit together and the potential connections: 1. One-Carbon Metabolism and Methylation: The Central Hub One-carbon metabolism (OCM) is a network of biochemical reactions that centers on the transfer of single-carbon units, primarily methyl groups ( CH 3 ). This pathway is essential for life and is directly tied to methylation. Methylation: The primary methyl donor for nearly all methylation reactions in the body is a molecule called S-adenosylmethionine (SAM) , which is produced by the OCM pathway (specifically the methionine cycle ). Methylati...