https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-200 So depression is an inflammatory disease, but where does the inflammation come from? Michael Berk Email author , Lana J Williams , Felice N Jacka , Adrienne O’Neil , Julie A Pasco , Steven Moylan , Nicholas B Allen , Amanda L Stuart , Amie C Hayley , Michelle L Byrne and Michael Maes BMC Medicine 2013 11 :200 https://doi.org/10.1186/1741-7015-11-200 © Berk et al.; licensee BioMed Central Ltd. 2013 Received: 8 February 2013 Accepted: 31 May 2013 Published: 12 September 2013 Open Peer Review reports Abstract Background We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex syst...