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Inflammation and Neurological Health

https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-200

So depression is an inflammatory disease, but where does the inflammation come from?

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BMC Medicine201311:200
https://doi.org/10.1186/1741-7015-11-200
©  Berk et al.; licensee BioMed Central Ltd. 2013
  • Received: 8 February 2013
  • Accepted: 31 May 2013
  • Published: 
Open Peer Review reports

Abstract

Background

We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. The obvious question this poses is ‘what is the source of this chronic low-grade inflammation?’

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