Specialized Pro-resolving Mediators: Getting Rid of Chronic Inflammation (geneticlifehacks.com) This is a very good article concerning out of control inflammation which is major problem that cascades in to more complex issues. Here is a snippet, the link above has the complete article. Chronic inflammation is due to lack of resolution Currently, if you go to the doctor with a disease that is caused by chronic inflammation, you will often be prescribed an anti-inflammatory medication. Something to block the formation of inflammatory cytokines, such as NSAIDs or leukotriene inhibitors. For example, TNF-alpha is an inflammatory cytokine that elevates in rheumatoid arthritis. Medications that block TNF, such as anti-TNF antibodies, are used to decrease the symptoms in RA. But the side effects include a suppressed immune system that makes patients more susceptible to pathogens. But why does TNF-alpha stay elevated in RA? One big part of the picture seems to be an inadequate or i...