Research Articles

What is  Akkermansia  and how does it work? Named after its preferred energy source,  Akkermansia muciniphila  feeds on mucin, a glycoprotein that regulates the thickness of our gut’s intestinal mucosal layer (6). As a byproduct of munching on mucin,  Akkermansia  produces propionate and acetate, two short-chain fatty acids (SCFAs) that feed other beneficial gut bacteria to make butyrate, a SCFA and vital energy source for mucus-secreting goblet cells and intestinal epithelial cells. Scientists call this cross-feeding. SCFAs strengthen tight junctions (the glue that holds our intestinal cells together) and prevent unwanted materials from passing through and into circulation. Think of your gut lining as a coffee filter, it lets the good stuff (coffee) in and keeps the bad stuff (coffee grinds) out. Here, the “bad stuff” represents allergens, endotoxins, fecal matter, and food particles, and the “good stuff” represents macro and micronutrients from real whole...

 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7733684/

  Andrographolide Andrographolide (AG) is not just any herb. In fact, it’s not an herb at all. It’s a chemical compound that comes from an herb called  Andrographis paniculata  found in India, China, and Australia. Andrographolide is used extensively in Chinese and Indian medicine. While its anti-inflammatory, antibacterial, antivirus, antitumor, and cardiovascular protecting properties have excited many, its low  bioavailability  has been a problem. That problem has prompted much work to create more potent derivatives. AG has been well studied, leaving the medical literature studded with reviews. Over the past couple of decades, hundreds of derivatives have been developed and bioavailability has been improved. A 2020 review of the many efforts made to improve the usefulness of this  unique compound demonstrated how active the andrographolide field is. There’s clearly still work to be done, though. While lauding the “ancient mighty herb” – and its perh...

A very interesting piece on the use of heat to treat infections.   Hyperthermia

 https://www.smithsonianmag.com/science-nature/copper-virus-kill-180974655/

  105-Year-Old Man In Italy Discovered With An Immune System Of A 25-Year Old CXCL9 Protein In Blood Determines “How Far Along A Person Is In Their Inexorable March To The Grave.” Red Wine Molecule May Produce Biologically Young Centenarians Researchers at Stanford University and the Buck Institute announce the remarkable discovery of a biological clock in human blood that can determine your “ inflammatory age” (iAge) which equates with longevity .  iAge can now be used to track risk to develop chronic age-related frailty.  Anticipate blood test kits to be available soon. Read more

  https://www.healthrising.org/blog/2019/02/08/metabolomics-chronic-fatigue-syndrome-oxidative-stress-low-oxygen/ Oxidative stress is the culprit.