Highlight • Oxidative damage to membrane phospholipids occurs in essentially all chronic and acute medical conditions, cancer and aging. • Membrane Lipid Replacement with glycerolphospholipids replaces damaged phospholipids and restores membrane and cellular functions. • Clinical trials have shown the benefits of Membrane Lipid Replacement in restoring mitochondrial function and reducing symptoms. • Membrane Lipid Replacement can also be used to remove toxic chemicals and other substances due to a ‘bulk flow’ mechanism. • Oral Membrane Lipid Replacement supplements are safe, inexpensive, effective and convenient. Abstract Membrane Lipid Replacement is the use of functional, oral supplements containing mixtures of cell membrane glycerolphospholipids, plus fructooligosaccharides (for protection against oxidative, bile acid and enzymatic damage) and antioxidants, in order to safely replace damaged, oxidized, membrane phospholipids and restore membr...