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Showing posts from June, 2021

Membrane Lipid Replacement Therapy

Highlight • Oxidative damage to membrane phospholipids occurs in essentially all chronic and acute medical conditions, cancer and aging. • Membrane Lipid Replacement with glycerolphospholipids replaces damaged phospholipids and restores membrane and cellular functions. • Clinical trials have shown the benefits of Membrane Lipid Replacement in restoring mitochondrial function and reducing symptoms. • Membrane Lipid Replacement can also be used to remove toxic chemicals and other substances due to a ‘bulk flow’ mechanism. • Oral Membrane Lipid Replacement supplements are safe, inexpensive, effective and convenient. Abstract Membrane Lipid  Replacement is the use of functional, oral supplements containing mixtures of cell membrane glycerolphospholipids, plus  fructooligosaccharides  (for protection against oxidative,  bile acid  and enzymatic damage) and antioxidants, in order to safely replace damaged, oxidized,  membrane phospholipids  and restore membr...

Researchers uncover hidden antibiotic potential of cannabis

  CBG appears to have the greatest effect of all the cannabinoids. It is able to disperse biofilms and penetrate gram negative bacteria, which is great news.  McMaster University. "Researchers uncover hidden antibiotic potential of cannabis: May serve as a lead for new drug development." ScienceDaily. ScienceDaily, 26 February 2020. <www.sciencedaily.com/releases/2020/02/200226131325.htm>.

Uncovering the Hidden Antibiotic Potential of Cannabinoids

  Maya A Farha   1   2 ,  Omar M El-Halfawy   1   2   3 ,  Robert T Gale   1   2 ,  Craig R MacNair   1   2 ,  Lindsey A Carfrae   1   2 ,  Xiong Zhang   1   2 ,  Nicholas G Jentsch   1   2 ,  Jakob Magolan   1   2 ,  Eric D Brown   1   2 Affiliations  expand PMID:  32017534   DOI:  10.1021/acsinfecdis.9b00419 Abstract The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating the exploration of alternative therapies.  Cannabis sativa  has long been known to contain antibacterial cannabinoids, but their potential to address antibiotic resistance has only been superficially investigated. Here, we show that cannabinoids exhibit antibacterial activity against methicillin-resistant  Staphylococcus aureus  (MRSA), inhibit its ability to form biofilms, and eradicate pre...

COVID-19 Coronavirus: Is Infection along with Mycoplasma or Other Bacteria Linked to Progression to a Lethal Outcome?

  Link to Article Abstract Most patients with COVID-19 disease caused by the SARS-CoV-2 virus recover from this infection, but a significant fraction progress to a fatal outcome. As with some other RNA viruses, co-infection or activation of latent bacterial infections along with pre-existing health conditions in COVID-19 disease may be important in determining a fatal disease course.  Mycoplasma  spp. ( M. pneumonaie, M. fermentans , etc.) have been routinely found as co-infections in a wide number of clinical conditions, and in some cases this has progressed to a fatal disease. Although preliminary,  Mycoplasma pneumoniae  has been identified in COVID-19 disease, and the severity of some signs and symptoms in progressive COVID-19 patients could be due, in part, to  Mycoplasma  or other bacterial infections. Moreover, the presence of pathogenic  Mycoplasma  species or other pathogenic bacteria in COVID-19 disease may confer a perfect storm of...

Antibacterial Activity of Unconjugated and Conjugated Bile Salts on Staphylococcus aureus

  Thippeswamy H. Sannasiddappa 1*† ,   Peter A. Lund 2   and   Simon R. Clarke 1* 1 School of Biological Sciences, University of Reading, Reading, United Kingdom 2 Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom Bile salts are potent antimicrobial agents and are an important component of innate defenses in the intestine, giving protection against invasive organisms. They play an important role in determining microbial ecology of the intestine and alterations in their levels can lead to increased colonization by pathogens. We have previously demonstrated survival of the opportunistic pathogen  Staphylococcus aureus  in the human colonic model. Thus investigating the interaction between  S. aureus  and bile salts is an important factor in understanding its ability to colonize in the host intestine. Harnessing bile salts may also give a new avenue to explore in the development of th...

The Glutathione System: A New Drug Target in Neuroimmune Disorders

 https://link.springer.com/article/10.1007/s12035-014-8705-x The Glutathione System: A New Drug Target in Neuroimmune Disorders Gerwyn Morris ,  George Anderson ,  Olivia Dean ,  Michael Berk ,  Piotr Galecki ,  Marta Martin-Subero  &  Michael Maes   Molecular Neurobiology   volume  50 ,  pages 1059–1084 ( 2014 ) Cite this article 2740  Accesses 93  Citations 16  Altmetric Metrics details Abstract Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by reacting directly with reactive oxygen or nitrogen species or by acting as an essential cofactor for GSH  S -transferases and glutathione peroxidases. GSH acting in concert with its dependent enzymes, known as the glutathione system, is responsible for the detoxification of reactive oxygen and nitrogen species (ROS/RNS) and electrophiles produced by xenobiotics. Adequate levels of GSH are essential for the optimal func...

Dr. Ron Davis Presents ME/CFS Research at the 2018 IIMEC Conference

Of note, viruses tend not to be a problem and he points out that protozoa (trypanosome) resemble CFS. He notes that antivirals may do more harm than good.