Skip to main content

Uncovering the Hidden Antibiotic Potential of Cannabinoids

 Maya A Farha 1 2, Omar M El-Halfawy 1 2 3, Robert T Gale 1 2, Craig R MacNair 1 2, Lindsey A Carfrae 1 2, Xiong Zhang 1 2, Nicholas G Jentsch 1 2, Jakob Magolan 1 2, Eric D Brown 1 2

Affiliations 

Abstract

The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating the exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address antibiotic resistance has only been superficially investigated. Here, we show that cannabinoids exhibit antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), inhibit its ability to form biofilms, and eradicate preformed biofilms and stationary phase cells persistent to antibiotics. We show that the mechanism of action of cannabigerol is through targeting the cytoplasmic membrane of Gram-positive bacteria and demonstrate in vivo efficacy of cannabigerol in a murine systemic infection model caused by MRSA. We also show that cannabinoids are effective against Gram-negative organisms whose outer membrane is permeabilized, where cannabigerol acts on the inner membrane. Finally, we demonstrate that cannabinoids work in combination with polymyxin B against multidrug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids.

Comments

Post a Comment

Popular posts from this blog

Patrick Gut Environment

\ Keywords to use in further research, GALT, tight junction proteins, Mucin layer, microbiome in MECFS or Long Covid, Goblet cells.   It was great chatting with you the other day. I’ve put together this general overview, but as I mentioned, you’ll definitely want to do your own deeper research. This is a very complex, interactive environment, and you’ll naturally come across many different opinions about what’s happening. Most opinions tend to focus on single layers, but as I’ve discovered, these layers are highly interconnected and influence one another. I don’t want to oversimplify things, nor do I want to overcomplicate them. It takes time to truly understand the gut environment in its proper context. I’m also cautious about saying “do X and you’ll get Y,” because results are rarely that straightforward. When I introduce layered therapies, I look for subtle changes across a list of markers I track. That’s why I believe this should be approached with care and patience—though I’m ...
Post a Comment
Read more

Caleb

I am constantly upgrading my protocols, which means I streamline. I went from taking individual supplements to revising this to a "container' idea, which means I think in systems rather than individual things. This is easier to manage. I will list my systems and how I approach this. I also have listed in terms of financial considerations, meaning I listed the most cost effective and best results.   Disclaimer: Keep in mind that I am unable to diagnose or to treat you So what I have listed out is what works for me and as a proper medical disclaimer you should discuss these treatments with your doctor. The video series will help understand the material better and I have additional information there. The videos could have been edited better if I had more time ;(. Thank you for your patience.    Video Series 1. B asic nutrients - this is foundational . I placed it at the number one spot . The reason for this is that my background was heavily into nutrients due t...
Post a Comment
Read more

Gut environment

 OK let's go back over the scenario Somebody gets a gut bug that could be viral or bacterial and we're going to put in the context of either long COVID or MECFS Let's discuss what exactly happens of how the body begins to adapt to this insult p — let’s build this cleanly, structurally, and without drama. This is the core terrain‑mechanics model of what happens when someone gets a gut bug (viral or bacterial) and then develops a long‑tail condition like long COVID or ME/CFS . This is the architecture that explains why the system never fully resets . I’ll walk you through it in chronological order , layer by layer, so you can see exactly how the body adapts — and why those adaptations become the trap. ⭐ 1. The Initial Insult Terrain layer: immune activation, epithelial irritation, redox stress A viral or bacterial gut infection does three things immediately: damages epithelial cells strips mucin spikes inflammatory cytokines This creates: redox collapse increased permeabil...
Post a Comment
Read more