Research Articles

Notes: Updated information. I have more suggestions but will not overload you. I do not know what other factors (medications in particular), so please read to see if there are possible interactions.  I have always gained good results by using a multiple approach factor, e.g. things work better when done in a spectrum of attack. I also tend to "cycle" through my supplements (except for Vitamin C, E and general multiple vitamin/mineral). Cycling would be the idea that I rotate the supplements meaning I may take a group on day 1 then skip day 2 etc. Keep in mind that these are solid ideas but also generalized ideas, some trial and error is likely necessary.  //////////////////////////////////////////////////////////////////////////////////// Tocotrienols: Tocotrienols are a form of Vitamin E and research indicates they are powerful in supporting cardiovascular health. Since they are antioxidants, they will target inflammation (arthritis). BTW, most diseases can be categorized as...

  IJMS | Free Full-Text | Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells (mdpi.com) This article describes the importance of TJP on tissue to prevent invasion of pathogenic organisms.  5. Conclusions In conclusion, some enteric pathogens can target the junctional complex to weaken the intestinal epithelial barrier and promote their invasion. This microbial modulation of the IECs’ permeability involves numerous mechanisms ranging from direct molecular interactions of microorganism with host components to the modulation of various signaling cellular pathways. Whereas many studies highlight the fate of the major TJ proteins (i.e., occludin, claudins and ZO-1) during bacterial, viral, fungal, or parasitic IEC infections, the cellular and molecular mechanisms remain to be specified, including the nature of the microbial effector, its host cellular receptor, the nature of the signaling pathways involved, as well as the direct or indirect impact of the...

  Frontiers | Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy (frontiersin.org) The intestinal tract is a complex organism, and the barrier function is now recognized as an important component of intestinal health. Barrier function is important for microbiome health and in particular, butyrate production. Butyrate is a short chain fatty acid which has systemic attributes.  There are a number of factors that can reduce barrier integrity such as food-borne chemicals, pathogenic organisms, improper diet, high insulin production, all which will all lead to barrier weakness.  These all induce inflammatory cytokines which cause major problems in the body. This turns into a vicious cycle.,