Intestinal Barrier Efficiency (Metabolic Diseases)

Frontiers | Enhancing intestinal barrier efficiency: A novel metabolic diseases therapy (frontiersin.org)

The intestinal tract is a complex organism, and the barrier function is now recognized as an important component of intestinal health. Barrier function is important for microbiome health and in particular, butyrate production. Butyrate is a short chain fatty acid which has systemic attributes.

There are a number of factors that can reduce barrier integrity such as food-borne chemicals, pathogenic organisms, improper diet, high insulin production, all which will all lead to barrier weakness. These all induce inflammatory cytokines which cause major problems in the body. This turns into a vicious cycle.,

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Paneth Cells - guardians of the intestinal tract

Click for the AI slideshow: https://sl.bing.net/hBioK3sTdDw From Google Gemini: Paneth Cells: The Guardians of the Gut Paneth cells are specialized epithelial cells found at the base of the intestinal crypts (small invaginations in the intestinal lining). They play a crucial role in maintaining the gut's health by acting as a first line of defense against harmful microorganisms. Key Functions: Antimicrobial Defense: Paneth cells produce and secrete a variety of antimicrobial peptides and proteins, such as lysozyme, defensins, and phospholipase A2. These substances help to kill bacteria, fungi, and other pathogens that may invade the intestinal tract. Regeneration of Intestinal Epithelium: Paneth cells contribute to the maintenance and regeneration of the intestinal lining by supporting the stem cells located nearby. Immune Regulation: These cells participate in regulating the immune response within the gut, helping to balance the body's reaction to both beneficial and ha...

Pizza

Notes: Updated information. I have more suggestions but will not overload you. I do not know what other factors (medications in particular), so please read to see if there are possible interactions. I have always gained good results by using a multiple approach factor, e.g. things work better when done in a spectrum of attack. I also tend to "cycle" through my supplements (except for Vitamin C, E and general multiple vitamin/mineral). Cycling would be the idea that I rotate the supplements meaning I may take a group on day 1 then skip day 2 etc. Keep in mind that these are solid ideas but also generalized ideas, some trial and error is likely necessary. //////////////////////////////////////////////////////////////////////////////////// Tocotrienols: Tocotrienols are a form of Vitamin E and research indicates they are powerful in supporting cardiovascular health. Since they are antioxidants, they will target inflammation (arthritis). BTW, most diseases can be categorized as...

Hi Holly's Daughter

Here are some general notes of the education I had in the Gut Environment. Keep in mind that this is educational and not a directive to treatment or diagnosis. As a side note, I spent an inordinate amount of time in this pursuit based on my own situation. I went to countless doctors and specialists to "resolve" my issues with little to no help. I personally have done these therapies countless times. I also hosted a forum on protozoa parasites and dives into antibiotic resistance. I did many stool samples (microbiology) to detect what bug I had contracted and did many therapies including antibiotics, probiotics and the like. Here is what I know. The Gastrointestinal Tract: The GI system is rather a complex organism that has many features that Western Medicine is just acknowledging at this point. The GI tract houses 70% of the immune response and these immune responses can react to both pathogens that enter the gut but also systemic infections (example a viral infection). In ...

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