T We had a conversation on Twitter you can read The initial posting my response and for follow up MECFS, MCAS and PTSD @FatigueMe92484 · 22h I just watched the PRIME weiner on MECFS. Two interesting talks showed increased lactate in MECFS. People with lower energy levels showed high lactate levels on visual stimulation test. As noted, lactate levels should not be found in the brain unless something metabolically is Show more Patrick Bayer @Patrick33264855 · 11h Energy shifts due to metabolic stress >OxPhos is the normal energy in healthy people but MECFS go into glycolysis which is related to lactate production. Cells do not run well on glycolysis - buffering agents are needed to reduce lactate. MECFS, MCAS and PTSD @FatigueMe92484 Yeah, unfortunately I have more than one variant that mat affect lactate levels. The GRIN2A variant, a PDHA1 variant and one that makes it harder for my cells to run on OXPHOS. Not much is known about the 3rd one. That Twitter exchange is a perfect r...