Skip to main content

Damage by Reactive Oxygen

This article discusses the problem with oxidative stress in which tissues, cells and organs are damaged as a result of this stress. The article discusses the role of antioxidants and the protection they provide to the oxidative damage. The author discusses the problems with getting the antioxidants where they can provide the most good. Liposomal delivery seems to be a good idea according to the article.



Abstract

Reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide, and hydroxyl radical, can be formed as normal products of aerobic metabolism and can be produced at elevated rates under pathophysiological conditions. Overproduction and/or insufficient removal of ROS result in significant damage to cell structure and functions. In vitro studies showed that antioxidants, when applied directly and at relatively high concentrations to cellular systems, are effective in conferring protection against the damaging actions of ROS, but results from animal and human studies showed that several antioxidants provide only modest benefit and even possible harm. Antioxidants have yet to be rendered into reliable and safe therapies because of their poor solubility, inability to cross membrane barriers, extensive first-pass metabolism, and rapid clearance from cells. There is considerable interest towards the development of drug-delivery systems that would result in the selective delivery of antioxidants to tissues in sufficient concentrations to ameliorate oxidant-induced tissue injuries. Liposomes are biocompatible, biodegradable, and nontoxic artificial phospholipid vesicles that offer the possibility of carrying hydrophilic, hydrophobic, and amphiphilic molecules. This paper focus on the use of liposomes for the delivery of antioxidants in the prevention or treatment of pathological conditions related to oxidative stress.

Comments

Post a Comment

Popular posts from this blog

Paneth Cells - guardians of the intestinal tract

  Click for the AI slideshow: https://sl.bing.net/hBioK3sTdDw From Google Gemini: Paneth Cells: The Guardians of the Gut Paneth cells are specialized epithelial cells found at the base of the intestinal crypts (small invaginations in the intestinal lining). They play a crucial role in maintaining the gut's health by acting as a first line of defense against harmful microorganisms. Key Functions: Antimicrobial Defense: Paneth cells produce and secrete a variety of antimicrobial peptides and proteins, such as lysozyme, defensins, and phospholipase A2. These substances help to kill bacteria, fungi, and other pathogens that may invade the intestinal tract. Regeneration of Intestinal Epithelium: Paneth cells contribute to the maintenance and regeneration of the intestinal lining by supporting the stem cells located nearby. Immune Regulation: These cells participate in regulating the immune response within the gut, helping to balance the body's reaction to both beneficial and ha...
Post a Comment
Read more

Pizza

Notes: Updated information. I have more suggestions but will not overload you. I do not know what other factors (medications in particular), so please read to see if there are possible interactions.  I have always gained good results by using a multiple approach factor, e.g. things work better when done in a spectrum of attack. I also tend to "cycle" through my supplements (except for Vitamin C, E and general multiple vitamin/mineral). Cycling would be the idea that I rotate the supplements meaning I may take a group on day 1 then skip day 2 etc. Keep in mind that these are solid ideas but also generalized ideas, some trial and error is likely necessary.  //////////////////////////////////////////////////////////////////////////////////// Tocotrienols: Tocotrienols are a form of Vitamin E and research indicates they are powerful in supporting cardiovascular health. Since they are antioxidants, they will target inflammation (arthritis). BTW, most diseases can be categorized as...
Post a Comment
Read more

Hi Holly's Daughter

Here are some general notes of the education I had in the Gut Environment. Keep in mind that this is educational and not a directive to treatment or diagnosis.  As a side note, I spent an inordinate amount of time in this pursuit based on my own situation. I went to countless doctors and specialists to "resolve" my issues with little to no help. I personally have done these therapies countless times. I also hosted a forum on protozoa parasites and dives into antibiotic resistance.  I did many stool samples (microbiology) to detect what bug I had contracted and did many therapies including antibiotics, probiotics and the like. Here is what I know. The Gastrointestinal Tract: The GI system is rather a complex organism that has many features that Western Medicine is just acknowledging at this point. The GI tract houses 70% of the immune response and these immune responses can react to both pathogens that enter the gut but also systemic infections (example a viral infection). In ...
Post a Comment
Read more