Skip to main content

Paneth Cells - guardians of the intestinal tract

 

Click for the AI slideshow:

https://sl.bing.net/hBioK3sTdDw



From Google Gemini:

Paneth Cells: The Guardians of the Gut

Paneth cells are specialized epithelial cells found at the base of the intestinal crypts (small invaginations in the intestinal lining). They play a crucial role in maintaining the gut's health by acting as a first line of defense against harmful microorganisms.

Key Functions:

  • Antimicrobial Defense: Paneth cells produce and secrete a variety of antimicrobial peptides and proteins,
     such as lysozyme, defensins, and phospholipase A2. These substances help to kill bacteria, fungi, and other pathogens that may invade the intestinal tract.
  • Regeneration of Intestinal Epithelium: Paneth cells contribute to the maintenance and regeneration of the intestinal lining by supporting the stem cells located nearby.
  • Immune Regulation: These cells participate in regulating the immune response within the gut, helping to balance the body's reaction to both beneficial and harmful bacteria.

Structure and Location:

Paneth cells are characterized by their prominent eosinophilic granules, which contain the antimicrobial substances they produce. They are typically located at the bottom of the intestinal crypts, where they are in close proximity to intestinal stem cells.

Image of Paneth cells in the intestinal crypt Opens in a new window www.frontiersin.org

Role in Gut Health:

The proper functioning of Paneth cells is essential for maintaining a healthy gut environment. Dysregulation of these cells has been implicated in various gastrointestinal diseases, including inflammatory bowel disease (IBD).

Comments

Post a Comment

Popular posts from this blog

Dementia Research

Disclaimer: I am not a doctor so I cannot diagnose or offer treatments, I am sharing this information that is considered educational. Much of the research on dementia/Alzheimer's is centered on what is referred to as Tight Junction Proteins. These are proteins that act like clamps that hold tissues together in terms of neurological, these "clamps" hold the blood vessels together. And when the tight junction proteins become damaged, the blood vessels begin to "leak".  Science refers the tight junction proteins as barrier as in the blood brain barrier. They will also refer to as barrier integrity. AI says this:  Tight junction proteins are vital for various physiological processes, including the formation of barriers in the brain (blood-brain barrier), intestines, and other tissues. They also play a role in disease mechanisms when their function is disrupted. The barrier function occurs in the blood vessels, and they think that when they leak, this is affecting co...
Post a Comment
Read more

Microbiome SCFAs & AutoImmunity

  Does SCFA impact immune and inflammatory pathways? Show thinking Yes, absolutely! Short-Chain Fatty Acids (SCFAs) are major players in controlling immune and inflammatory pathways, both within the gut and systemically. This is one of the most significant and exciting areas of research on SCFAs. Here's how they exert their control: Interaction with G-Protein Coupled Receptors (GPCRs): GPR41 and GPR43: These are the most well-studied SCFA receptors, found on various cell types throughout the body, including immune cells (e.g., neutrophils, macrophages, T cells), gut epithelial cells, and adipocytes. When SCFAs (particularly acetate, propionate, and butyrate) bind to these receptors, they trigger intracellular signaling pathways that can influence immune cell function, cytokine production, and inflammatory responses. Histone Deacetylase (HDAC) Inhibition: Butyrate (and to a lesser extent propionate) are potent inhibitors of HDACs. HDACs are enzymes that modify histones, proteins aro...
Post a Comment
Read more
You can buy most of this at Kroger's, I listed the pictures below. The idea is that you are targeting the gut, the microbiome to be exact. I am not going to list out all the studies but they have discovered that the right bacteria in the gut can change a lot of things including metabolic, neurological, immune responses, weight gain and many other things.  Increasing the good bacteria such as bifidobacteria etc. can also suppress the bad bacteria which have been linked to numerous problems.  There are products that you can buy on Amazon and these will also support the microbiome by giving the nutrients they need.  Kroger's has the ones in the pictures below, you will find the Cleveland Kraut in the refrigerated section and so is the Kefir. Both of these are live foods meaning they contain the good bacteria. Sauerkraut as canned does not work since there are no live organisms.  You will have to experiment with the doses; I do a couple of tablespoons of the kraut and ju...
Post a Comment
Read more