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Evaluation of antibacterial activity against spirochetes of Lyme


Lyme disease is debilitating and Western medicine is not proficient in treating it. The disease is caused by spirochete bacteria, they are known to be resistant. This article explores natural medicines to kill the spirochetes. The text below is a significant part of the study. 

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738477/

 Our study has shown that the most promising compounds effective against spirochete and latent rounded forms of both tested Borrelia sp. were cis‐2‐decenoic acid, baicalein, monolaurin and kelp (iodine). They demonstrated bacteriostatic and bactericidal effects in a time‐dependent manner against spiral and rounded forms. We are aware that fluorescence staining used in our study may not reveal few persisting rounded forms that may grow out from a population treated with the ‘drug of choice’; however, this would be relatively a small population. At the same time, these compounds, except kelp (iodine), revealed mild or moderate cytotoxic effect on human HepG2 cell line at their MBCs concentrations. However, no significant cytotoxic effects were observed at their MICs concentrations. In addition, while cis‐2‐decenoic acid, luteolin, baicalein, monolaurin and kelp (iodine) were effective against biofilm‐like colonies of B. burgdorferi, only baicalein and monolaurin showed significant reduction in biofilm of B. garinii,although at 1·5–2 times higher concentrations than those needed to induce bactericidal effect. This could be due to different biofilm morphologies, as B. burgdorferi forms more a colony‐like and scattered structure and B. garinii forms a layered and very condense assembly. These morphological differences might affect biofilm penetration by various compounds or signal different pathophysiological effects. Interestingly, doxycycline was effective against the spirochete form of both tested Borrelia sp. and displayed moderate effect against biofilm, but not against dormant rounded forms. These results correspond to findings reported by Sapi, et al. (Sapi et al. 2011).

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