Skip to main content

Evaluation of antibacterial activity against spirochetes of Lyme


Lyme disease is debilitating and Western medicine is not proficient in treating it. The disease is caused by spirochete bacteria, they are known to be resistant. This article explores natural medicines to kill the spirochetes. The text below is a significant part of the study. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738477/

Our study has shown that the most promising compounds effective against spirochete and latent rounded forms of both tested Borrelia sp. were cis‐2‐decenoic acid, baicalein, monolaurin and kelp (iodine). They demonstrated bacteriostatic and bactericidal effects in a time‐dependent manner against spiral and rounded forms. We are aware that fluorescence staining used in our study may not reveal few persisting rounded forms that may grow out from a population treated with the ‘drug of choice’; however, this would be relatively a small population. At the same time, these compounds, except kelp (iodine), revealed mild or moderate cytotoxic effect on human HepG2 cell line at their MBCs concentrations. However, no significant cytotoxic effects were observed at their MICs concentrations. In addition, while cis‐2‐decenoic acid, luteolin, baicalein, monolaurin and kelp (iodine) were effective against biofilm‐like colonies of B. burgdorferi, only baicalein and monolaurin showed significant reduction in biofilm of B. garinii,although at 1·5–2 times higher concentrations than those needed to induce bactericidal effect. This could be due to different biofilm morphologies, as B. burgdorferi forms more a colony‐like and scattered structure and B. garinii forms a layered and very condense assembly. These morphological differences might affect biofilm penetration by various compounds or signal different pathophysiological effects. Interestingly, doxycycline was effective against the spirochete form of both tested Borrelia sp. and displayed moderate effect against biofilm, but not against dormant rounded forms. These results correspond to findings reported by Sapi, et al. (Sapi et al2011).

Comments

Popular posts from this blog

Paneth Cells - guardians of the intestinal tract

  Click for the AI slideshow: https://sl.bing.net/hBioK3sTdDw From Google Gemini: Paneth Cells: The Guardians of the Gut Paneth cells are specialized epithelial cells found at the base of the intestinal crypts (small invaginations in the intestinal lining). They play a crucial role in maintaining the gut's health by acting as a first line of defense against harmful microorganisms. Key Functions: Antimicrobial Defense: Paneth cells produce and secrete a variety of antimicrobial peptides and proteins, such as lysozyme, defensins, and phospholipase A2. These substances help to kill bacteria, fungi, and other pathogens that may invade the intestinal tract. Regeneration of Intestinal Epithelium: Paneth cells contribute to the maintenance and regeneration of the intestinal lining by supporting the stem cells located nearby. Immune Regulation: These cells participate in regulating the immune response within the gut, helping to balance the body's reaction to both beneficial and ha...

Hi Holly's Daughter

Here are some general notes of the education I had in the Gut Environment. Keep in mind that this is educational and not a directive to treatment or diagnosis.  As a side note, I spent an inordinate amount of time in this pursuit based on my own situation. I went to countless doctors and specialists to "resolve" my issues with little to no help. I personally have done these therapies countless times. I also hosted a forum on protozoa parasites and dives into antibiotic resistance.  I did many stool samples (microbiology) to detect what bug I had contracted and did many therapies including antibiotics, probiotics and the like. Here is what I know. The Gastrointestinal Tract: The GI system is rather a complex organism that has many features that Western Medicine is just acknowledging at this point. The GI tract houses 70% of the immune response and these immune responses can react to both pathogens that enter the gut but also systemic infections (example a viral infection). In ...

Pizza

Notes: Updated information. I have more suggestions but will not overload you. I do not know what other factors (medications in particular), so please read to see if there are possible interactions.  I have always gained good results by using a multiple approach factor, e.g. things work better when done in a spectrum of attack. I also tend to "cycle" through my supplements (except for Vitamin C, E and general multiple vitamin/mineral). Cycling would be the idea that I rotate the supplements meaning I may take a group on day 1 then skip day 2 etc. Keep in mind that these are solid ideas but also generalized ideas, some trial and error is likely necessary.  //////////////////////////////////////////////////////////////////////////////////// Tocotrienols: Tocotrienols are a form of Vitamin E and research indicates they are powerful in supporting cardiovascular health. Since they are antioxidants, they will target inflammation (arthritis). BTW, most diseases can be categorized as...