Sulforaphane and Other Nutrigenomic Nrf2 Activators

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736808/#

Excerpt:

3.3. Broccoli Sprout versus Broccoli Vegetable
Much of the clinically relevant Brassica research relates to broccoli sprouts [49] rather than to the mature vegetable, with most of the early work in this field done by a group at the Johns Hopkins University beginning in the early 1990s. The group found that 3-day-old sprouts of cultivars of certain crucifers contained 10–100 times higher concentration of GRN than the corresponding mature plants [49]. With a focus on identifying plants with cancer chemopreventive properties, they found that the sprouts were highly effective in reducing the incidence, multiplicity, and rate of development of mammary tumors in dimethylbenz(a)anthracene-treated rats. Broccoli sprouts also had the added advantage of containing mostly the methylsulfinylalkyl glucosinolate (75% of the total) and very little of the indole glucosinolate found in the mature plant, which is a potential tumor promoter [50]. Their realization was that small quantities of broccoli sprouts may protect against cancer as effectively as much larger quantities of the vegetable stimulated subsequent research.

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Paneth Cells - guardians of the intestinal tract

Click for the AI slideshow: https://sl.bing.net/hBioK3sTdDw From Google Gemini: Paneth Cells: The Guardians of the Gut Paneth cells are specialized epithelial cells found at the base of the intestinal crypts (small invaginations in the intestinal lining). They play a crucial role in maintaining the gut's health by acting as a first line of defense against harmful microorganisms. Key Functions: Antimicrobial Defense: Paneth cells produce and secrete a variety of antimicrobial peptides and proteins, such as lysozyme, defensins, and phospholipase A2. These substances help to kill bacteria, fungi, and other pathogens that may invade the intestinal tract. Regeneration of Intestinal Epithelium: Paneth cells contribute to the maintenance and regeneration of the intestinal lining by supporting the stem cells located nearby. Immune Regulation: These cells participate in regulating the immune response within the gut, helping to balance the body's reaction to both beneficial and ha...

Hi Holly's Daughter

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