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Gut microbiota, kynurenine pathway and mental disorders

 https://www.sciencedirect.com/science/article/abs/pii/S0278584620304619


Highlights

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Among several possible tryptophan metabolism routes, the kynurenine pathway can be influenced by the gut microbiota.

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Changes in gut biodiversity may cause increased gut permeability and cause systemic and central nervous system inflammation.

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Proinflammatory cytokines induce kynurenine pathway resulting in formation of metabolites linked with some mental disorders.

Abstract

The intestine and the gut-associated limphoid tissue constitute the largest immunity organ of the human body. Among several possible tryptophan metabolism routes, the kynurenine pathway can be influenced by the gut microbiota. Disturbances of gut biodiversity may cause increased gut permeability and cause systemic inflammation, also related to central nervous system. Proinflammatory cytokines induce kynurenine pathway enzymes resulting in formation of neuroactive metabolites, which are being associated with several psychiatric disorders. The kynurenine pathway may also be influenced by certain bacteria species directly. The aim of this review is to highlight the current knowledge on the interaction of gut microbiota and the central nervous system with the kynurenine pathway taken into special account. Up to date study results on specific psychiatric disorders such as schizophrenia, bipolar disorder, Alzheimer's disease, autism spectrum disorders, depression and alcoholism are presented. Available evidence suggests that toxicity of kynurenine metabolites may be reduced by adjunction of probiotics which can affect proinflammatory cytokines. Due to their potential for modulation of the kynurenine pathway, gut microbiota pose an interesting target for future therapies.

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