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Metaformin and Antibiotic Resistance

 


Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria


Introduction

The continuous increase in the incidence of bacterial resistance to existing antibiotics represents a worldwide health burden. A surrogate strategy to combat such crisis is to find compounds that restore the antimicrobial activity of the already existing antibiotics against multidrug resistant bacteria. Metformin is a commonly used antidiabetic medication. It has proven benefits in other diseases including cancer, aging-related and infectious diseases. In this study, the potential effect of metformin as an adjuvant therapy to antibiotics was investigated.


Consistent with our findings, several previous published studies showed that metformin has the potential to be used in combination with other antibiotics,, and metformin can reduce the resistance of bacteria and efficiently restore the efficacy of the antibiotics. These studies along with other studies confirm the antimicrobial potential of metformin either alone or in combination, not only with antibacterial,,, but also with antifungal, antiprotozoal, and anti-tuberculosis effects.,

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8123943/

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