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Polyphenols as Inhibitors of Antibiotic Resistance & Biofilm (Rutin)

 Polyphenols as Inhibitors of Antibiotic Resistant Bacteria—Mechanisms Underlying Rutin Interference with Bacterial Virulence - PMC (nih.gov)


Derivatives of quercetin, taxifolin, rutin, and isoquercitrin have shown promising antibacterial capacity, along with morin. 



2.4. Rutin Significantly Affected Urinary Catheter Biofilms

2.8. Rutin Suppresses P. aeruginosa IBRS P001 Virulence Factors Production

2.10. Rutin’s Impact on Cell Membrane Permeability


5. Conclusions

The potential of polyphenols to combat the growth of antibiotic resistant bacteria in both planktonic and biofilm forms was confirmed in this study as well as the non-cytotoxic nature for the majority of the plant bioactive molecules examined. Rutin, as the most active representative, was proven to strongly affect the formation of bacterial biofilms in vitro as confirmed by a range of biofilm models and assays used. Likewise, rutin was able to reduce the production of P. aeruginosa virulence factors and to downregulate the expression of quorum sensing related genes of this pathogen. Its antimicrobial mechanism might be related to interference with membrane permeability. Rutin should be further studied and could be used for the development of novel antimicrobial therapeutics that might be efficient in combating antibiotic-resistant bacteria.

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