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TLR4

From the article

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects | PLOS ONE


 Due to the high number of extracts tested, we focused on the ten most effective anti-inflammatory extracts identified on screening. These included Castanea sativa leaves, Cinchona pubescens bark, Cinnamomum verum bark, Salix alba bark, Rheum palmatum root, Alchemilla vulgaris plant, Humulus lupulus cones, Vaccinium myrtillus berries, Curcuma longa root and Arctostaphylos uva-ursi leaves. To the best of our knowledge, Castanea sativa leaves and Alchemilla vulgaris plant extracts had not been reported to modulate the NF-κB, TLR2 or TLR4 signaling pathways, thus representing new promising candidates for further investigations. However, spiny burrs of sweet chestnuts inhibited NF-κB activation in vivo [26] and ellagitannins present in Alchemilla vulgaris were shown to possess NF-κB dependent anti-inflammatory effects [27]


Castanea Sativa  = Sweet Chestnut

Chinchona Pubescens bark = Chinchona tree from South America - most know it from Quinine 

Cinnamomum vernum bark = Ceylon Cinnamon (this is different than cinnamon at the store, that cinnamon is Cassia Cinnamon - it is said that Cassia has some toxic qualities, I use Ceylon.

Salix alba bark =  White Willow - I believe this was how they extracted aspirin or the chemical salicin.

Rheum palmatum root = Chinese Rhubarb

Alchemila vulgaris =  Lady's Mantle

Humulus lupulus cones = Hops - much research on its health promoting activity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782902/

Vaccium myrtillus = Bilberry - rich in anthocyanins which are an amazing class of polyphenols

https://www.ncbi.nlm.nih.gov/books/NBK92770/

Curcuma longa = turmeric

Arctostaphylos uva-ursi leaves = Uva Ursi




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