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Regulation of the intestinal barrier by nutrients: The role of tight junctions

Tight Junctions protect the intestinal complex - good tight junctions stop inflammation. This article discusses some of the roles of nutrients in creating good tight junctions. This includes polyphenols, sugars, fats, proteins, vitamins and minerals. Great article.


Quercetin, Resveratrol (pterostilbene), naringenin (Citrus Grapefruit), 

Naringenin,daidzein, hesperetin, morin, and myricetin enhance the integrity of the TJ barrier, whereas chrysin decreases TJ integrity (Noda,

 Regulation of the intestinal barrier by nutrients: The role of tight junctions - PMC (nih.gov)


Looks like dietary fiber can play a significant role in SCFA since it helps proliferate beneficial bacteria.

Previous studies also found that there was a correlation between mucosal gene expression levels and SCFA concentration. Butyrate-producing bacteria (Fusobacteria) were positively correlated with tight junction protein (ZO-1) expression levels. Acetate, propionate, caproate, and branched-chain fatty acids could stimulate the expression of short-chain fatty acid receptors (free fatty acid receptor 2 [FFAR2] and FFAR3) and barrier-related genes (mucin 4 [MUC4]) (, , ). In our study, Dietary Fiber (DF) increased the relative abundance of Fusobacteria and improved the intestinal barrier function, which may be related to the increase of the concentrations of acetate, propionate, butyrate, and branched-chain fatty acids. The study of Xu et al. () also showed that the addition of DF (inulin or pectin) increased the number of butyrate-producing bacteria (Fusobacteria and Proteobacteria) in the intestinal contents of piglets and also increased the expression levels of tight junction proteins (ZO-1 and occludin) (, ).

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