Research Articles

A study that links pyruvate dehydrogenase problems in M.E. Pyruvate dehydrogenase is part of the Krebs cycle and when it is low then energy output suffers. The Krebs cycle is a complex study on the production of energy, when the Krebs cycle output is low then the energy production slows. Imagine running a factory that requires adequate energy to produce products, but what if the energy is not adequate, then production slows or ceases. People who suffer with M.E. suffer from low energy (low Krebs) and as a result, the functions of the body suffer including neurological, immune, detoxification, endocrine and a whole host of other issues. The Krebs Cycle is dependent on raw nutrients to do its thing, if the raw materials are not there then the cycle does not function or becomes aberrant. This article looks at the complex nature of amino acids in the formation of pyruvate dehydrogenase. Vitamin co-factors and minerals are necessary for amino acid formation. Metabolic profi...

This is an excellent article which outlines the delicate balance in the body. It focuses on the NEI System which is the Neurological, Endocrine and Immunity. These 3 systems are intertwined and when one becomes imbalanced, then the others do as well. Stress comes in many forms such as emotional which is the widely understood one but stress also comes from mental (overwork), biochemical stress which includes infection, improper nutrition, trauma etc. This article looks at psychosocial and the role of drugs aimed at GABA receptors. GABA is the calming neurotransmitter which counteracts glutamate which is the angry neurotransmitter. By addressing the stressors, the immune and endocrine systems will begin to behave. Traditional Chinese Medicine understands the balance of the systems and they know by addressing these, the patient will become balanced and well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679551/ GABAergic modulation with classical benzodiazepines prevent s...

Copper along with other minerals, play a key role in human health. Copper participates in many key roles in the body including immunity, joint, muscle, detoxification and others. This article explores the use of copper from the past. Innovations June 2000 From Copper.org Medical Uses of Copper in Antiquity Copper Applications in Health & Environment The first recorded medical use of copper is found in the Smith Papyrus, one of the oldest books known. The Papyrus is an Egyptian medical text, written between 2600 and 2200 B.C., which records the use of copper to sterilize chest wounds and to sterilize drinking water. Other early reports of copper's medicinal uses are found in the Ebers Papyrus, written around 1500 B.C. The Ebers Papyrus documents medicine practiced in ancient Egypt and in other cultures that flourished many centuries earlier. Copper compounds were recommended for headaches, "trembling of the limbs" (perhaps referring to epilepsy or St....

Abstract A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with a consideration of the post-infection role of damage-associated molecular patterns and the development of chronic inflammatory, oxidative and nitrosative stress in genetically predisposed individuals. The consequences are detailed, including the role of increased intestinal permeability and the translocation of commensal antigens into the circulation, and the development of dysautonomia, neuroinflammation, and neurocognitive and neuroimaging abnormalities. Increasing levels of such stress and the switch to immune and metabolic downregulation are detailed next in relation to the advent of hypernitrosylation, impaired mitochondrial performance, immune suppression, cellular hibernation, endotoxin tolerance and sirtuin 1 activation. The role of chronic stress and the development of endotoxin tolerance...

Bacteria—especially Gram-negative strains—are becoming increasingly resistant to current antibiotic drugs, and the development of new classes of antibiotics has slowed. Faced with these challenges, investigators are studying the potential of combination therapy, in which two or more drugs are used together to increase or restore the efficacy of both drugs against a resistant bacterial pathogen. Now new research indicates that such synergy may work even when bacteria become resistant to colistin, which is considered a treatment agent of last resort. The findings are especially promising because recent evidence indicates the potential for rapid worldwide spread of colistin resistance. “For an infected patient, if the multidrug-resistant Gram-negative bacterial pathogen is resistant to colistin, then there is a big problem,” said senior author James Kirby, MD, Director of the Clinical Microbiology Laboratory at BIDMC. Read more  https://www.technologynetworks.com/neuroscience/n...

Methylation is an important pathway in your body that controls a number of things including immunity, detoxification, energy production, gene expression, mental and behavioral issues and others. Methylation, along with most other processes require certain nutrients to work correctly. There can be situations where methylation is over-expressed or under-expressed or preferably be in balance. The link below is a comprehensive review of imbalanced methylation. Here is an excerpt: While there are a number of potential factors that may cause mental illness, one that many people don’t consider is that of methylation. It is believed that genetic mutations may lead to abnormalities in the methylation process. The methylation cycle is a specific biochemical pathway that is responsible for influencing a variety of critical biological processes including: the immune system, DNA maintenance, production of energy, and detoxification. During the methylation process, neurotransmitters are cre...

Agonists and Antagonists in nutrients. This is a vital concept meaning that there are many relationships that exist among nutrients, if you lean too heavily on one, then others are likely to be suppressed. cancercelltreatment.com