Research Articles

    A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications - PubMed (nih.gov) Piper nigrum  and its bioactive compounds were also found to possess important pharmacological properties . Antimicrobial activity was recorded against a wide range of pathogens via inhibition of biofilm, bacterial efflux pumps, bacterial swarming, and swimming motilities.   Studies also reported its antioxidant effects against a series of reactive oxygen and nitrogen species including the scavenging of superoxide anion, hydrogen peroxide, nitric oxide, DPPH, ABTS, and reducing effect against ferric and molybdenum (VI). Improvement of antioxidant enzymes  in vivo  has also been reported.  Piper nigrum  also exhibited anticancer effect against a number of cell lines from breast, colon, cervical, and prostate through different mechanisms including cytotoxicity, apoptosis, autophagy, and interference with signaling pathways. It...

  Hypothesis Predicts Major Failure Point in Chronic Fatigue Syndrome (ME/CFS) - Health Rising They proposed that two factors – sympathetic nervous system hyperactivity and ß2AdR receptor problems – are knocking the blood vessels of people with ME/CFS for a loop. As sympathetic nervous system hyperactivity is giving them a good squeeze, the ß2AdR receptors which are supposed to open them up are getting hammered by the immune system. That leaves the blood vessels unable to deliver the proper amounts of blood to the muscles, brain, organs, etc. The body, of course, can’t have that and so it attempts to fix the situation by releasing vasodilators like bradykinin and prostaglandins. The authors believe these vasodilators spill over into the bloodstream where they, alas, produce fatigue, pain, and flu-like symptoms as well as headaches, gut pain, cognitive and sleep problems.

  FOR IMMEDIATE RELEASE ​ Orthomolecular Medicine News Service, February 1, 2022 ​ How COVID Helped Me Regain Good Health ​ Editorial by Thomas E. Levy, MD, JD ​ ​ OMNS (Feb. 1, 2022) Most truly healthy people do not actually realize they are healthy, especially if they have never had a significant chronic disease or infection. And that is a normal reaction to being healthy. You just enjoy life without being focused on multiple ways in which you might eventually become unhealthy. Someone who has never suffered with headaches is not going to marvel that they are headache-free. Someone who has never had heartburn after a beer and pizza is not going to marvel at how good their stomach and gut feel afterwards. The person who is completely healthy and has always been so, who appreciates how precious that health is, and who works hard at doing everything possible to stay healthy is the rarest of individuals. Most people who are working hard at staying healthy have already been significan...

  Formation of Reactive Oxygen Species and Cellular Damage Reactive oxygen species (ROS) are molecules containing an oxygen atom with an unpaired electron in its outer shell. As ROS are formed, they become very unstable due to the unpaired electron now residing in the outermost shell. The unstable forms of oxygen are sometimes called free radicals. How do ROS actually get generated in cells? One way is via cellular respiration driven by the  electron transport  chain in the mitochondria. The electron transport chain is responsible for generating ATP, the main source of energy for a cell to function. A key molecule that helps “jump start” the electron transport chain, is NADH (or nicotinamide adenine dinucleotide), which serves as the electron donor (i.e., the H in the NADH). NADH is often referred to as a “coenzyme”, even though it is not an enzyme (a protein). NADH is present in all cells–it is generated by many biochemical reactions. One way that NADH gets generate...

 Very good article  - covers resistance, Cell permeability, Biofilms etc.  Frontiers | Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria | Microbiology (frontiersin.org)

 1. INTRODUCTION Antibiotic resistance is a current problem that occurs in different countries of the world (Odonkor and Addo, 2011). As is known, acute respiratory infections and diarrheal infections occupy the first places in diseases of infectious origin, however systemic infections are also present among the human population, being difficult to treat due to the multiple cases of resistance to antibiotics (Atiaa et al., 2020). Currently, the search for new substances with antimicrobial activity is frequent by different research groups in the world, especially the study of compounds of natural origin with antimicrobial properties. In this context, various extracts of plant origin have shown multiple antibacterial and antibiofilm properties (Dogruoz et al., 2008). It has been reported that medicinal plants have been used for therapeutic purposes since ancient times 3.pdf (arcjournals.org)